Dominic Lopez is a major drug lord based out of San Maria. He runs drugs, everything from cocaine to Surge, all over the country. His biggest competitors are the Bertelli Crime Syndicate and the McMannus Mob Family.

He evades the law while still being able to run one of the biggest drug empires in the nation's history. He is allegedly responsible for a large fraction of the city's crime, and is reported to have been responisble for upwards of 40 murders.

He fronts as a buisnessman out of his nightclub, Dominic's.